It is entirely possible that some people may be more effective at producing pregnenolone than others, and therefore better able to adjust after consuming THC. When treating human cell lines with the hormone, scientists found similar results.
Not only did the injection reduce THC intoxication, but the rodents were less likely to self-administer THC after the fact. In another experiment, the scientists injected the rodents with pregnenolone after treating them with THC. They noticed that the rodents began to produce pregnenolone in response, as if the hormone which seemed to block the effects of the THC. In the study, researchers treated rodents with very high levels of THC. Like cannabis, it also is thought to have a slight negative effect on memory and can make you sleepy. People take it to improve mood, ease anxiety, and enhance brain function. Interestingly, you can buy this hormone online and at vitamin supplement stores. Pregnenolone is thought to protect the brain from cannabis intoxication. The hormone in question is pregnenolone, which is a naturally occurring hormone in the body. Research published in 2014 in the journal Science found that a particular hormone may block you from experiencing a cannabis high. I don’t have a medical condition, why am I not high?Īpart from specific medical conditions, there is another reason why some people may not experience a cannabis high after consuming THC. The outcome of your high may be dependent on your endocannabinoid tone in the first place. If this is the case, those with some of these conditions may experience cannabis a bit differently than others. Some mental health conditions like post-traumatic stress disorder and bipolar disorder may also have some sort of endocannabinoid disfunction. Specifically, those with migraine, fibromyalgia, and IBS. Russo theorizes that people with certain medical conditions may not produce enough of these endocannabinoids in the first place. This system is the largest neurotransmitter network in the body, and it controls a variety of key bodily functions. By doing so, THC taps into a larger network called the endocannabinoid system. When you inhale or eat the psychoactive plant, THC hijacks the cell receptor that human endocannabinoids would normally land. Humans naturally produce their own versions of cannabis, called endocannabinoids. Ethan Russo thinks that some people may have what is called an endocannabinoid deficiency. There is some early, theoretical evidence to back up these claims. It’s not uncommon to hear people with fibromyalgia or post-traumatic stress disorder explain that cannabis gives them energy and makes them feel soberer. Some people with certain medical conditions, for example, consume the herb and feel more normal.
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